Question

Conserved functional sites can be identified by profile and hidden Markov model–based motif and domain search tools such as SMART and InterPro.

(a) True

(b) False

This question was posed to me in class test.

This is a very interesting question from Genome Annotation in portion Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

The correct choice is (a) True

For explanation I would say: Detecting remote homologs typically involves combined searches of protein motifs and domains and prediction for secondary and tertiary structures. The prediction can also be performed using structure-based approaches such as threading and fold recognition.