Question

Which of the following is incorrect regarding genome economy?

(a) It is a phenomenon of synthesizing more proteins from fewer genes

(b) This is a major strategy that eukaryotic organisms use to achieve a myriad of genotypic diversities only

(c) This is a major strategy that eukaryotic organisms use to achieve a myriad of phenotypic diversities

(d) There are numerous underlying genetic mechanisms to help account for genome economy

I have been asked this question in class test.

Origin of the question is Genome Annotation in division Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

Right option is (b) This is a major strategy that eukaryotic organisms use to achieve a myriad of genotypic diversities only

To elaborate: A major mechanism responsible for the protein diversity is alternative splicing, which refers to the splicing event that joins different exons from a single gene to form different transcripts. A related mechanism, known as exon shuffling, which joins exons from different genes to generate more transcripts, is also common in eukaryotes. It is known that, in humans, about two thirds of the genes exhibit alternative splicing and exon shuffling during expression, generating 90% of the total proteins.