Question

Which of the following is incorrect regarding Automated Genome Annotation?

(a) It exists because of the need to develop fast and automated methods to annotate the genomic sequences

(b) The automated approach relies on homology detection

(c) The automated approach doesn’t rely on heuristic sequence similarity searching

(d) Automation brings speed in gene annotation process

The question was asked in a national level competition.

This intriguing question comes from Genome Annotation topic in division Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

Right answer is (c) The automated approach doesn’t rely on heuristic sequence similarity searching

Best explanation: If a newly sequenced gene or its gene product has significant matches with a database sequence beyond a certain threshold, a transfer of functional assignment is taking place. In addition to sequence matching at the full length, detection of conserved motifs often offers additional functional clues.