Question

The drawback of Homology-based approach is its reliance on the presence of homologs in databases.

(a) True

(b) False

This question was posed to me in an interview.

Query is from Gene Prediction in Eukaryotes topic in portion Gene and Promoter Prediction of Bioinformatics

Answer 1

The correct choice is (a) True

For explanation: If the homologs are not available in the database, the method cannot be used. Novel genes in a new species cannot be discovered without matches in the database. A number of publicly available programs use this approach.