Question

GENSCAN is awebbased program that makes predictions based on fifth-order HMMs.

(a) True

(b) False

I had been asked this question in a job interview.

My query is from Gene Prediction in Eukaryotes in section Gene and Promoter Prediction of Bioinformatics

Answer 1

Correct choice is (a) True

For explanation I would say: It combines hexamer frequencies with coding signals (initiation codons, TATA box, cap site, poly-A, etc.) in prediction. Putative exons are assigned a probability score (P) of being a true exon. Only predictions with P > 0.5 are deemed reliable. This program is trained for sequences from vertebrates, Arabidopsis, and maize. It has been used extensively in annotating the human genome.