Question

TwinScan is also a similarity-based gene-finding Server and it is similar to GenomeScan in that it uses GenScan to predict all possible exons from the genomic sequence.

(a) True

(b) False

The question was asked in unit test.

Enquiry is from Gene Prediction in Eukaryotes in division Gene and Promoter Prediction of Bioinformatics

Answer 1

Right option is (a) True

The best I can explain: The putative exons are used for BLAST searching to find closest homologs. The putative exons and homologs from BLAST searching are aligned to identify the best match. Only the closest match from a genome database is used as a template for refining the previous exon selection and exon boundaries.