Question

CpGProD is a web-based program that predicts promoters containing a high density of CpG islands _______

(a) in archea genomic sequences

(b) in mammalian genomic sequences

(c) in eukaryotic and bacterial genomic sequences

(d) only in bacterial genomic sequences

I had been asked this question by my school principal while I was bunking the class.

My question is based upon Prediction Algorithms in chapter Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

Correct answer is (b) in mammalian genomic sequences

To explain: It calculates moving averages of GC% and CpG ratios (observed/expected) over a window of a certain size (usually 200 bp). When the values are above a certain threshold, the region is identified as a CpG island.