Question

Which of the following is incorrect regarding CONPRO?

(a) It is a web-based program that uses a consensus method

(b) It is used to identify promoter elements for human DNA

(c) cDNA does not play a role in prediction

(d) The program uses the information to search the human genome database for the position of the gene

I got this question in an online quiz.

My enquiry is from Prediction Algorithms in section Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

Right option is (c) cDNA does not play a role in prediction

For explanation: To use the program, a user supplies the transcript sequence of a gene (cDNA). It then uses the GENSCAN program to predict 5’ untranslated exons in the upstream region. Once the 5’-most exon is located, a further upstream region (1.5 kb) is used for promoter prediction, which relies on a combination of five promoter prediction programs, TSSG, TSSW, NNPP, PROSCAN, and PromFD.