Question

Which of the following is incorrect regarding Eponine?

(a) It is a web-based program that predicts transcription start sites

(b) It is a web-based program that particularly predicts tranpososons and retropososons

(c) The regulatory sites include the TATA box, the CCAAT box, and CpG islands

(d) It is based on a series of pre-constructed PSSMs of several regulatory sites

This question was addressed to me in a job interview.

This intriguing question originated from Prediction Algorithms topic in section Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

The correct option is (b) It is a web-based program that particularly predicts tranpososons and retropososons

The explanation is: The query sequence from a mammalian source is scanned through the PSSMs. The sequence stretches with high-score matching to all the PSSMs, as well as matching of the spacing between the elements, are declared transcription start sites. A Bayesian method is also used in decision making.