Question

Which of the following is incorrect regarding Phylogenetic Footprinting–Based Method?

(a) It is possible to obtain promoter sequences for a particular gene through comparative analysis

(b) The conservation from closely related organisms is both at the sequence level and at the level of organization of the elements

(c) The conservation from closely related organisms is most at the sequence level

(d) It has been observed that promoter and regulatory elements from closely related organisms such as human and mouse are highly conserved

The question was posed to me by my college director while I was bunking the class.

This key question is from Prediction Algorithms topic in chapter Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

Right answer is (c) The conservation from closely related organisms is most at the sequence level

To explain: The identification of conserved noncoding DNA elements that serve crucial functional roles is referred to as phylogenetic footprinting; the elements are called phylogenetic footprints. This type of method can apply to both prokaryotic and eukaryotic sequences.