Question

Each genome sequence is scanned for protein-encoding genes using gene models trained on known gene sequences from the same organism.

(a) True

(b) False

I have been asked this question in an internship interview.

My doubt is from Sequence Assembly and Gene Identification in chapter Collecting & Storing Sequences in Laboratory of Bioinformatics

Answer 1

The correct option is (a) True

To explain: For a new genome, each predicted gene is translated into a protein sequence; the collection of protein sequences encoded by the genome is the proteome of the organism. every protein in the proteome is then used as a query sequence in a database similarity search. Matching database sequences are realigned with the query sequence to evaluate the extent and significance of the alignment.