Question

Which of the given statement is incorrect?

(a) As in an all-by-all protein comparison within a proteome, a matrix of alignment scores with E values is made, and the most closely related sequences in the two organisms are identified

(b) To perform a between-proteome analysis, proteome databases are made for the known and predicted genes of two or more genomes

(c) Each protein of one proteome is selected in turn as a query of the proteome of another organism or the combined proteome of a group of organisms

(d) Each protein of one proteome is selected in turn as a query of the proteome of another single organism only

This question was posed to me in class test.

This intriguing question comes from Sequence Assembly and Gene Identification in division Collecting & Storing Sequences in Laboratory of Bioinformatics

Answer 1

Correct choice is (d) Each protein of one proteome is selected in turn as a query of the proteome of another single organism only

Easiest explanation: This analysis can predict orthologs. In other words proteins have an identical function attributable to descent of the respective genes from a common ancestor.