Question

In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.

(a) True

(b) False

This question was posed to me during an online interview.

The query is from The Use of Gene Order & Phylogeny to Predict Protein topic in division Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Right answer is (a) True

The best I can explain: As mentioned, one third of such pairs were found to physically interact. The phylogenetic patterns of clusters of orthologous groups of proteins deposited in the COG database of Koonin and co-workers could in principle be used for prediction in the same way.