Question

Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.

(a) True

(b) False

The question was asked during an online interview.

My doubt stems from The Use of Gene Order & Phylogeny to Predict Protein in section Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Correct option is (a) True

To elaborate: Most domain families engage in interactions with one or two other types of families, but a few families are very versatile and interact with many families. These versatile families are ubiquitously useful families such as P-loop nucleotide triphosphate hydrolases and Rossmann domains.