Question

Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.

(a) not applicable to archea genomes

(b) not applicable to prokaryote genomes

(c) applicable to eukaryote genomes

(d) not applicable to eukaryote genomes

The question was posed to me in a job interview.

Query is from The Use of Gene Order & Phylogeny to Predict Protein topic in portion Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Correct option is (d) not applicable to eukaryote genomes

To explain: Co-regulation of genes in eukaryotes can be inferred by similarity in the expression patterns of genes. A comparison of co-expressed yeast and worm genes showed that 90% of those pairs of genes with conserved co-expression are members of stable complexes. Thus, the principle of conserved co-regulation across distantly related organisms applies to stable complexes in both prokaryotes and eukaryotes, and can be used as a prediction tool in both.