Question

Which of the given statement is incorrect about the Chromosomal Rearrangements?

(a) Comparison of the number of rearrangements in a given period of evolutionary history may vary significantly from one organism to the next

(b) If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, there is an increased probability of an ortholog of B also occurring in the other organism

(c) If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, the B ortholog is more likely to be a neighbor of the A ortholog of the genome of the second species if the two species are more divergent

(d) In general, the order of orthologs is not well conserved in prokaryotes when the genomes have diverged sufficiently that the orthologs have < 50% identity

I have been asked this question in a national level competition.

Question is from Functional Classification of Genes in chapter Genome Analysis of Bioinformatics

Answer 1

Right option is (c) If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, the B ortholog is more likely to be a neighbor of the A ortholog of the genome of the second species if the two species are more divergent

Best explanation: The B ortholog is less likely to be a neighbor of the A ortholog of the genome of the second species if the two species are more divergent. By classifying genes using a nine class functional classification scheme, several genes falling into the same functional category are clustered together on the chromosomes of both of these organisms, and the clusters are in a similar order.