Question

Which of the given statement is incorrect?

(a) Paralogous sequences, frequently are found to have dissimilar functions

(b) An early classification scheme for eight related groups of E. coli genes included categories for enzymes, transport elements

(c) An early classification scheme for eight related groups of E. coli genes included categories for regulators, membranes, structural elements, protein factors, leader peptides, and carriers

(d) Ninety percent of E. coli genes related by significant sequence similarity fell into these same broad categories

This question was posed to me in an internship interview.

My question is from Functional Classification of Genes in chapter Genome Analysis of Bioinformatics

Answer 1

Right choice is (a) Paralogous sequences, frequently are found to have dissimilar functions

The explanation: Genes that are significantly similar in an organism, i.e., paralogous sequences, frequently are found to have a related biological function. This discovery follows the expected origin of paralogs by gene duplication events, leaving one copy to perform the original function and producing a second copy to develop a new function not too distant from the original one under evolutionary selection.