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When was the genetic basis of retinoblastoma first explained?

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in Cell Biology by (121k points)
When was the genetic basis of retinoblastoma first explained?

(a) 1961

(b) 1971

(c) 1981

(d) 1991

This question was posed to me in an internship interview.

This intriguing question originated from Cancer topic in portion Cancer of Cell Biology

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Right answer is (b) 1971

Explanation: The genetic basis of retinoblastoma was first explained in 1971 by Alfred Knudson at the University of Texas. Unlike other dominant genetic disorders, the carriers of gene responsible for retinoblastoma only develop a strong disposition towards developing the disease, rather than inheriting the disease itself.

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