Question

Bringing 2 kinase domains in close contact allows for ___________________

(a) trans-autophosphorylation

(b) cis-autophosphorylation

(c) inactivation of one domain

(d) inactivation of both domains

I had been asked this question during a job interview.

I want to ask this question from Cell Signaling and Signal Transduction in division Cell Signaling and Signal Transduction of Cell Biology

Answer 1

Right choice is (a) trans-autophosphorylation

For explanation I would say: When two domains of protein-tyrosine kinases come close, it leads to trans-autophosphorylation in which activity of one receptor of the dimer phosphorylates the tyrosine residue of the other.