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Which of these would you use as a competitive inhibitor for Cdt?

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Which of these would you use as a competitive inhibitor for Cdt?

(a) MCM 1

(b) MCM 2

(c) MCM 7

(d) MCM 10

I had been asked this question in homework.

This intriguing question comes from DNA Replication Eukaryotes topic in section DNA Replication of Cytogenetics

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Correct answer is (d) MCM 10

Explanation: MCM 10 replaces Cdt from pre-replication complex triggering the phosphorylation in the next step. Thus, it must have a similar structure to Cdt and can act as a competitive inhibitor. While there is no MCM 1, MCM 2-7 form a member helicase.

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