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Deletion of which domain of ARS would give the least replication rate in eukaryotes?

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Deletion of which domain of ARS would give the least replication rate in eukaryotes?

(a) A domain

(b) B1 domain

(c) B2 domain

(d) B3 domain

I got this question in unit test.

I'd like to ask this question from DNA Replication Eukaryotes topic in chapter DNA Replication of Cytogenetics

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The correct choice is (a) A domain

The best I can explain: The 11bp ‘A domain’ is the primary functional area of the ARS. Mutation in this domain gives 0% functionality of ORC so lease replication. Other mutations also reduce replication rate but not to such extent.

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