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In presence of Thyroid hormone the receptor TR binds to ____________

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In presence of Thyroid hormone the receptor TR binds to ____________

(a) RXR directly

(b) mRPD3 directly

(c) NcoR directly

(d) mRPD3 indirectly

The question was asked in examination.

My question is from Transcription in Eukaryotes : Chromatin Remodelling topic in portion Gene Expression : Transcription Prokaryotes of Cytogenetics

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The correct choice is (a) RXR directly

To explain I would say: In presence of thyroid hormone the receptor binds to RXR directly. In absence however, it binds to NcoR directly, which binds to SIN3 and mRPD3 which is an HDAC, this binding inactivates the genes.

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