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Which of these SIR proteins are having HDAC activity?

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Which of these SIR proteins are having HDAC activity?

(a) SIR1

(b) SIR2

(c) SIR3

(d) SIR4

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This intriguing question originated from Transcription in Eukaryotes : Gene Silencing at Telomere topic in portion Gene Expression : Transcription Prokaryotes of Cytogenetics

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The correct option is (b) SIR2

To elaborate: The SIR or silent information regulator proteins are responsible for repression at the telomere by deacetylating the histones. While SIR3and SIR4 bind to the N-termini the SIR2 protein which is attracted by SIR 3-4 is having the HDAC activity.

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