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RAP1 has a ___________________

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RAP1 has a ___________________

(a) Positive effect on transcription

(b) No effect on transcription

(c) Negative effect on transcription

(d) Immensely positive effect on transcription

This question was addressed to me in an online interview.

This interesting question is from Transcription in Eukaryotes : Gene Silencing at Telomere topic in section Gene Expression : Transcription Prokaryotes of Cytogenetics

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The correct choice is (c) Negative effect on transcription

Easy explanation: RAP1 is necessary for silencing at the telomere. As silenced gene can’t be expressed so it has a negative effect. The effect can be even called very negative as the silencing is very strong.

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