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Which of the following can’t be repaired by BER?

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Which of the following can’t be repaired by BER?

(a) Abasic sites

(b) Deamination

(c) CPD

(d) Oxidative damage

I got this question in quiz.

My question is from Repair of DNA Damage: MMR, BER in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

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Correct answer is (c) CPD

To explain: BER usually deals with single base damages, and NER takes care of the damages involving bulky lesions like CPD. Abasic site generation is the 1st step of BER process so it can carry out the reaction easily.

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