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In a synergistic model of initiation which of the following factor doesn’t directly lead to initiation?

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In a synergistic model of initiation which of the following factor doesn’t directly lead to initiation?

(a) eIF4E

(b) PAB1

(c) eIF4G

(d) Protein X

The question was posed to me during an online interview.

The origin of the question is Control of Translation in chapter Gene Expression : Translation of Cytogenetics

1 Answer

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Best answer
Correct choice is (d) Protein X

The best I can explain: In a synergistic model of initiation both the poly a tail and the G cap plays a role. So, PAB1 binds to the poly A tail and eIF4E binds to the 5’-G cap with the eIF4G acting as a linker. But protein X plays a role in IRES mode of initiation not this.

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