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Which of these is not an NMD factor?

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Which of these is not an NMD factor?

(a) DCP1

(b) Exonuclease

(c) EJC

(d) Ski 7

This question was posed to me during an internship interview.

My question is taken from Control of Translation topic in portion Gene Expression : Translation of Cytogenetics

1 Answer

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Right option is (b) Exonuclease

For explanation: NMD stands for nonsense mediated degradation which is responsible for degrading the mRNA prematurely when it has a nonsense mutation. Nonsense mutation can lead to a stop codon before the original stop codon. Here the only exonuclease also participates in normal turn over.

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