Question

In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement?

(a) The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability

(b) The particles reaggregate to form larger particles due to their high surface free energy

(c) Extreme reduction in the particle size imparts surface charges that may prevent wetting

(d) Extreme reduction in the size brings the hydrophobic amino acids to the surface

I had been asked this question in an interview for job.

My question is taken from Drugs Absorption topic in portion Absorption of Drugs of Drug Biotechnology

Answer 1

Right choice is (d) Extreme reduction in the size brings the hydrophobic amino acids to the surface

The explanation: In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Three reasons are, Hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability, the particles reaggregate to form larger particles due to their high surface free energy, extreme reduction in the particle size impart surface charges that may prevent wetting.