Question

Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.

(a) True

(b) False

I have been asked this question in an international level competition.

The origin of the question is Drugs Absorption in chapter Absorption of Drugs of Drug Biotechnology

Answer 1

Correct choice is (a) True

To elaborate: Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent. Example, NSAIDs like aspirin, ibuprofen and some penicillin analogues. Such drugs can be absorbed from acidic conditions of the stomach.