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Which of the sequence will Dcm methylate?

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Which of the sequence will Dcm methylate?

(a) GATC

(b) GAATC

(c) CCGTT

(d) CCAGG

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This interesting question is from Restriction Endonuclease in section Genomics : The Mapping and Sequencing of Genomes of Cytogenetics

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Right option is (d) CCAGG

Easy explanation: DCM methylates at the C base while DAM methylates at the A base. DCM methylates ta the internal C of the sequence CCAGG. The sequence CCGTT is not a palindrome and GATC is recognized and methylated by DAM.

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