Question

Which one is the correct sequence for drug absorption through the oral route?

(a) Absorption – Dissolution – Disintegration – Deaggregation

(b) Disintegration – Dissolution – Deaggregation – Absorption

(c) Disintegration – Deaggregation – Dissolution – Absorption

(d) Disintegration – Deaggregation – Absorption – Dissolution

This question was addressed to me during an interview.

This question is from Drug Absorption in portion Absorption of Drugs of Drug Biotechnology

Answer 1

The correct answer is (c) Disintegration – Deaggregation – Dissolution – Absorption

For explanation: Disintegration of the drug and then Deaggregation and subsequent release of a drug. Followed by the dissolution of the drug in aqueous fluids at the absorption site and the movement of the dissolved drug through the gastrointestinal membrane into the systemic circulation.