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Mut H acts as ______________

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Mut H acts as ______________

(a) Adaptor

(b) Exonuclease

(c) Endonuclease

(d) Helicase

This question was addressed to me at a job interview.

My enquiry is from Repair of DNA Damage: MMR, BER topic in chapter DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

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Best answer
The correct option is (c) Endonuclease

To explain: Mut H can bind to hemi-methylated DNA and make a nick in the strand with unmethylated GATC sequence. As it makes a nick within the DNA it is an endonuclease.

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