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Which of the following modes of repair is restricted to S phase of the cell cycle?

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Which of the following modes of repair is restricted to S phase of the cell cycle?

(a) BER

(b) MMR

(c) NER

(d) DSB

I had been asked this question in exam.

My query is from Repair of DNA Damage: MMR, BER topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

1 Answer

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Right option is (b) MMR

Explanation: MMR/mis-match repair system concerns the wrong bases incorporated by polymerase error while replication. It has to distinguish the parent and daughter strand for this repair. Since after replication completion and during division both the stands are indistinguishable, it is restricted to S phase.

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