Question

What happens when an obese person is given with a lipophilic drug?

(a) Drug aggregation will begin

(b) He cannot absorb lipophilic drugs

(c) High adipose tissue take up most of the lipophilic drug

(d) A large amount of drug is needed as the person’s weight is more

I got this question in my homework.

Question is taken from Drug Distribution in portion Distribution of Drugs of Drug Biotechnology

Answer 1

Right option is (c) High adipose tissue take up most of the lipophilic drug

For explanation I would say: The high adipose tissue in the obese person take up a large fraction of the lipophilic drugs. Though the perfusion through it is low. The high fatty acid levels in obese person alter the binding characteristics of acidic drugs.