Question

Which of the following drug cannot pass through the plasma membrane barrier?

(a) Drug size less than 50 Dalton

(b) Lipophilic drugs 50-600 Dalton

(c) Polar or ionized drugs of size greater than 50 Dalton

(d) Drug size more than 600 Dalton

The question was asked in examination.

Query is from Drug Distribution topic in chapter Distribution of Drugs of Drug Biotechnology

Answer 1

Correct answer is (d) Drug size more than 600 Dalton

Easy explanation: Drugs size of fewer than 50 Daltons can only pass the plasma membrane barrier. Lipophilic drugs of molecular weight 50-600 Dalton, polarised drugs of size greater than 50deltons can also pass the given membrane.