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Which is the earliest discovered prodrug?

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Which is the earliest discovered prodrug?

(a) Prontosil

(b) Sulphanilamide

(c) Aspirin

(d) Salicylic acid

I had been asked this question during an online exam.

This question is from Prodrugs topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

1 Answer

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Correct option is (a) Prontosil

To elaborate: Prontosil is the prodrug for the antibacterial agent sulfanamide in the body. It was the earliest prodrug discovered accidentally. Aspirin is the prodrug of salicylic acid used to reduce gastric irritation.

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