Question

Which of the following is not a characteristic of ideal prodrug?

(a) Should rapidly transform, chemically and enzymatically forming the active product

(b) Should have intrinsic pharmacological activity

(c) The vapour pressure should be less and evaporate easily

(d) Apart from an active product, other metabolic fragments should be nontoxic

The question was asked by my school principal while I was bunking the class.

The question is from Prodrugs topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer 1

Right choice is (c) The vapour pressure should be less and evaporate easily

Explanation: If the vapour pressure of any drug is more if will get converted into gaseous form and thus through exhalation it will be expelled out of the body. The characteristics of an ideal prodrug are, it should rapidly transform, chemically and enzymatically forming the active product, should have intrinsic pharmacological activity, the vapour pressure should be more and evaporate easily, and apart from an active product other metabolic fragments should be non-toxic.