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Phosphorylation of eIF4E-BP will affect translation in what way?

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Phosphorylation of eIF4E-BP will affect translation in what way?

(a) Increase

(b) Decrease

(c) No effect

(d) There is no such factor

I have been asked this question in an internship interview.

Question is from Initiation topic in portion Gene Expression : Translation of Cytogenetics

1 Answer

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Best answer
Correct choice is (a) Increase

The best I can explain: eIF4E-BP is the active form of the factor which can bind to the eIF4E and prevent translation. When phosphorylated, this binding is sterically prevented. Thus, phosphorylation increases translation generating free eIF4E.

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