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Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.

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Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.

(a) True

(b) False

I got this question in examination.

This interesting question is from Drugs Distribution in chapter Distribution of Drugs of Drug Biotechnology

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Right choice is (a) True

Best explanation: Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution. Other factors that influence the volume of distribution are changes in tissue perfusion, permeability, changes in physicochemical characteristics of the drug.

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