Question

What will bet the apparent volume of distribution of drugs which binds selectively to extravascular tissues?

(a) The apparent volume of distribution is less than the true volume of distribution

(b) The apparent volume of distribution is more than the true volume of distribution

(c) The apparent volume of distribution is equal to the true volume of distribution

(d) The apparent volume of distribution is equal to the volume of extravascular tissues

This question was posed to me during an online exam.

My query is from Drugs Distribution topic in chapter Distribution of Drugs of Drug Biotechnology

Answer 1

Correct answer is (b) The apparent volume of distribution is more than the true volume of distribution

Easy explanation: Drugs which binds selectively to extravascular tissues have an apparent volume of distribution is more than the true volume of distribution. The volume of distribution of these drugs is always greater than 42 litres or total body water volume. For example, chloroquine has volume distribution of approximately 15,000 litres.