Question

What will be the apparent volume of distribution of warfarin?

(a) The apparent volume of distribution is less than the true volume of distribution

(b) The apparent volume of distribution is more than the true volume of distribution

(c) The apparent volume of distribution is equal to the true volume of distribution

(d) Warfarin is not a medicine

I had been asked this question in my homework.

This key question is from Drugs Distribution topic in portion Distribution of Drugs of Drug Biotechnology

Answer 1

Right answer is (a) The apparent volume of distribution is less than the true volume of distribution

For explanation: Drugs which bind to plasma protein or other blood components such as that of warfarin, their apparent volume of distribution is less than the true volume of distribution. The volume of distribution of these drugs lies between blood volume and total body water volume.