Question

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 85 * Scr formula belong to?

(a) 1-6 years

(b) 1-20 years

(c) Males above 20 years

(d) Females above 20 years

The question was posed to me at a job interview.

This key question is from Pharmacokinetic in section Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

Correct choice is (d) Females above 20 years

To explain: Calculation of creatinine clearance involves the determination of serum creatinine levels. Creatinine production varies with age, height and gender. The given equation is for females whose age is above 20 years. Clcr is creatinine clearance in ml/min, Scr is serum creatinine in mg%, H is height in cms, W is weight in kg, age is in years.