Question

The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.

(a) True

(b) False

This question was posed to me in a national level competition.

I want to ask this question from Pharmacokinetic topic in portion Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

The correct answer is (a) True

Easiest explanation: When another drug displaces one drug which was previously bound to plasma protein, the renal clearance of the later increases. Gentamicin induced nephrotoxicity by furosemide is an example of this. Furosemide does not precipitate by its diuretic effect but by displacing gentamicin from binding sites.