Question

“Cascade lantentiation” concept takes into account which kind of prodrugs?

(a) Mixed type prodrugs

(b) Pro-prodrugs

(c) Bioprecursors

(d) Carrier linked prodrugs

The question was asked in an internship interview.

Origin of the question is Prodrugs in division Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer 1

Right answer is (b) Pro-prodrugs

To explain: In cases, when the drug has to be formulated in different other ways such as ophthalmic, parenteral, oral liquid, etc. The prodrugs are further derivative to a form where only enzymatic conversion to the prodrug has to be done before the later can be cleaved to give the active product.