Question

Which drugs can easily pass the Placental barrier?

(a) Drugs having a molecular weight less than 1000 Dalton

(b) Moderate to high lipid solubility

(c) Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics

(d) Analgesics, antibiotics, etc

The question was posed to me in a job interview.

The doubt is from Drug Distribution in division Distribution of Drugs of Drug Biotechnology

Answer 1

Correct answer is (c) Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics

The explanation is: Drugs having a molecular weight less than 1000deltons and drugs which are moderate to high lipophilic in nature can easily pass the placental barrier. For e.g. drugs such as ethanol, anesthetics, steroids, narcotic analgesics, and antibiotics, etc. can pass the placental barrier.