Question

Which of the following acts as a licensing factor for replication?

(a) ORC

(b) Cdt

(c) MCM

(d) CDC42

I have been asked this question by my college professor while I was bunking the class.

I need to ask this question from Cell Cycle Stages topic in division Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer 1

The correct answer is (c) MCM

To elaborate: MCM acts as the licensing factor to set on the M phase of cell cycle. In its absence, the ORC although present in the nucleus can’t reinitiate replication. Cdc6 participates in replication and not cdc42, cdt is bound by geminin and is not the licensing factor.