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What is the fate of cdc6 after origin firing?

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What is the fate of cdc6 after origin firing?

(a) It is sequestered by geminin

(b) It is phosphorylated and thus can no longer interact

(c) It is irreversibly bound to ORC

(d) It is phosphorylated, ubiquitin is added and destroyed

This question was posed to me during an online exam.

The query is from Cell Cycle Stages topic in portion Cancer Biology & Methods in Cytogenetics of Cytogenetics

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The correct choice is (d) It is phosphorylated, ubiquitin is added and destroyed

Explanation: The continued presence of CDC6 and MCM could lead to re-initiation of replication at the ORC. Thus, to prevent this, the CDC6 is phosphorylated and marked for destruction.

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