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Ataxia talengictesia is due to the defect in which of the following?

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Ataxia talengictesia is due to the defect in which of the following?

(a) P53

(b) Mdm2

(c) Cdc25

(d) Mad2

The question was asked by my college professor while I was bunking the class.

The doubt is from Cell Cycle Stages topic in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics

1 Answer

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Correct answer is (b) Mdm2

Easy explanation: The defect in Mdm2 when it is unable to phosphorylate p53 in response to DNA damage causes ataxia talengictesia. It is a genetic disorder that often leads to cancer.

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