Question

Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.

(a) True

(b) False

The question was asked by my college professor while I was bunking the class.

This interesting question is from Non Linearity of Drugs in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right option is (a) True

Easiest explanation: Some of the pharmacokinetic factors such as fraction bioavailable, elimination half-life or total systemic clearance at different doses of drug normally remains constant. If any changes occur in these constants, this indicates nonlinearity.