Question

Which equation plot is being shown in the picture?

(a) Michaelis-Menten plot

(b) One compartment characteristics graph

(c) Two compartment characteristics graph

(d) Two compartment administered extravascularly characteristics plot

The question was posed to me in examination.

I would like to ask this question from Non Linearity of Drugs topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Correct answer is (a) Michaelis-Menten plot

To explain: The plot is of Michaelis-Menten equation –dC/dt = Vmax C/Km+C, Initially the rate increases linearly with concentration thus showing first order kinetics. It becomes mixed order at higher concentration and then reaches maximum Vmax. Beyond this, it proceeds at a constant rate.